alerta/alertantes

English translation: trigger drugs

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Spanish term or phrase:alerta/alertantes
English translation:trigger drugs
Entered by: liz askew

15:50 Oct 13, 2022
Spanish to English translations [PRO]
Medical - Medical (general) / screening for adverse events
Spanish term or phrase: alerta/alertantes
Hello,

I am stuck on this in the following context:

Uso de fármacos alertantes para la detección de reacciones adversas intrahospitalarias: estudio de farmacovigilancia

En este contexto, los fármacos alertantes han demostrado ser útiles en la detección de posibles RAM. Dicho esto, es fundamental que la detección precoz de RAM y EM sea llevada a cabo por profesionales cualificados y experimentados, especialmente en el caso de pacientes añosos, que son el grupo que más habitualmente experimenta estos

En este sentido, reconociendo la importancia de promover la seguridad del paciente, el uso de fármacos alertantes es uno de los métodos que permite la identificación temprana de un EAM en un paciente6. Dichos fármacos constituyen una herramienta mucho más sensible y específica para la detección de RAM que otros métodos utilizados para evaluar los daños ocasionados al paciente13.

En Estados Unidos, el Institute for Healthcare Improvement (IHI) ha desarrollado, en base al análisis de historias clínicas, una serie de alertadores destinados a detectar EAM intrahospitalarios15. Los alertadores son datos o indicios en la historia clínica del paciente que advierten sobre un posible daño6.

Existen algunos medicamentos que se utilizan habitualmente como alertadores, tales como los antídotos y los antihistamínicos17


I am not convinced by findings of "trigger drugs" or "alert drugs".

Any help, withe evidence as back-up, would be appreciated.
liz askew
United Kingdom
Local time: 21:00
trigger drugs
Explanation:
Trigger tools


Triggers are used as a proactive tool for identifying adverse drug events. Triggers can be changes in a patient’s clinical condition, an abnormal labora-tory test or a prescription for a drug which might prompt investigation into a medicine-related cause of the event. Medicines which might be triggers for adverse drug events include vitamin K to reverse overanticoagulation in patients receiving warfarin, glucagon for insulin-induced hypoglycaemia, naloxone for opioid toxicity and flumazenil for oversedation with benzodi-azepines. Pharmacists should be prompted to investigate the reason why trigger drugs are prescribed and report any adverse drug reactions or medi-cation errors identified. Similarly, abnormal laboratory results may indicate medication-related problems. Elevated serum potassium levels may indicate inappropriate use of potassium-sparing diuretics and rapid falls in haemoglo-bin may indicate gastrointestinal bleeding in a patient receiving non-steroidal anti-inflammatory medicines. Pharmacists can use triggers to identify risks with medicines proactively, prevent patient harm by contributing to changes in medication regimens and report adverse incidents.

https://www.pharmacy180.com/article/identifying-risk-1658/

King's College Hospital NHS Foundation Trust in London is using a list of trigger drugs (drugs often used to treat patients after an adverse drug event) as a way to identify adverse drug events. Details of the scheme were reported to the conference by Georgina Boon, a pharmacist, and Gillian Cavell, deputy director of pharmacy at the trust.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018798/

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Note added at 2 hrs (2022-10-13 18:19:10 GMT)
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Medication Safety pharmacists at King’s College Hospital are sent a daily ‘trigger report’ listing adult inpatients who have been prescribed and administered trigger drugs on our electronic prescribing and medicines administration system (EPMA)

https://www.eahp.eu/sites/default/files/di-024_2.pdf



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Note added at 1 day 4 hrs (2022-10-14 20:48:40 GMT)
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I'm glad you've found it useful.
Selected response from:

Helena Chavarria
Spain
Local time: 22:00
Grading comment
Thanks!
4 KudoZ points were awarded for this answer



Summary of answers provided
5alert/alerting drugs
José Julián Díaz
3 +2trigger drugs
Helena Chavarria
3indicator drugs
Anne Schulz
Summary of reference entries provided
This might help.
Helena Chavarria

Discussion entries: 1





  

Answers


1 hr   confidence: Answerer confidence 5/5
alert/alerting drugs


Explanation:
https://pubmed.ncbi.nlm.nih.gov/2893422/

José Julián Díaz
Mexico
Local time: 14:00
Works in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 20
Login to enter a peer comment (or grade)

2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
trigger drugs


Explanation:
Trigger tools


Triggers are used as a proactive tool for identifying adverse drug events. Triggers can be changes in a patient’s clinical condition, an abnormal labora-tory test or a prescription for a drug which might prompt investigation into a medicine-related cause of the event. Medicines which might be triggers for adverse drug events include vitamin K to reverse overanticoagulation in patients receiving warfarin, glucagon for insulin-induced hypoglycaemia, naloxone for opioid toxicity and flumazenil for oversedation with benzodi-azepines. Pharmacists should be prompted to investigate the reason why trigger drugs are prescribed and report any adverse drug reactions or medi-cation errors identified. Similarly, abnormal laboratory results may indicate medication-related problems. Elevated serum potassium levels may indicate inappropriate use of potassium-sparing diuretics and rapid falls in haemoglo-bin may indicate gastrointestinal bleeding in a patient receiving non-steroidal anti-inflammatory medicines. Pharmacists can use triggers to identify risks with medicines proactively, prevent patient harm by contributing to changes in medication regimens and report adverse incidents.

https://www.pharmacy180.com/article/identifying-risk-1658/

King's College Hospital NHS Foundation Trust in London is using a list of trigger drugs (drugs often used to treat patients after an adverse drug event) as a way to identify adverse drug events. Details of the scheme were reported to the conference by Georgina Boon, a pharmacist, and Gillian Cavell, deputy director of pharmacy at the trust.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018798/

--------------------------------------------------
Note added at 2 hrs (2022-10-13 18:19:10 GMT)
--------------------------------------------------

Medication Safety pharmacists at King’s College Hospital are sent a daily ‘trigger report’ listing adult inpatients who have been prescribed and administered trigger drugs on our electronic prescribing and medicines administration system (EPMA)

https://www.eahp.eu/sites/default/files/di-024_2.pdf



--------------------------------------------------
Note added at 1 day 4 hrs (2022-10-14 20:48:40 GMT)
--------------------------------------------------

I'm glad you've found it useful.

Helena Chavarria
Spain
Local time: 22:00
Native speaker of: Native in EnglishEnglish
PRO pts in category: 381
Grading comment
Thanks!
Notes to answerer
Asker: Thank you for the convincing evidence!


Peer comments on this answer (and responses from the answerer)
agree  Erzsébet Czopyk: Impressive and profoundly elaborated.
1 hr
  -> Thank you very much, Erzsébet :-)

agree  neilmac
12 hrs
  -> Cheers, Neil :-)
Login to enter a peer comment (or grade)

3 days 55 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
alertadores/alertantes
indicator drugs


Explanation:
Proactive identification includes observation of medication passes, concurrent and retrospective review of a patient’s clinical records, ADR surveillance team, implementation of medication usage evaluations for high-alert drugs, and identification of indicator drugs that, when ordered, automatically generate a drug regimen review for a potential adverse drug event.
https://www.cms.gov/Regulations-and-Guidance/Guidance/Manual...

FWIW, I think that the other suggestions are as valid.

Anne Schulz
Germany
Local time: 22:00
Specializes in field
Native speaker of: German
PRO pts in category: 165
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Reference comments


30 mins peer agreement (net): +1
Reference: This might help.

Reference information:
IHI Trigger Tool for Measuring Adverse Drug Events
​Institute for Healthcare Improvement (in partnership with Premier, Inc., San Diego, California, USA)
Cambridge, Massachusetts, USA

The use of "triggers," or clues, to identify adverse drug events (ADEs) is an effective method for measuring the overall level of harm from medications in a health care organization. The Trigger Tool for Measuring Adverse Drug Events provides instructions for conducting a retrospective review of patient records using triggers to identify possible ADEs. This tool includes a list of known ADE triggers and instructions for measuring the number and degree of harmful medication events. The tool provides instructions and forms for collecting the data you need to measure ADEs per 1,000 Doses and Percent of Admissions with an ADE.

https://www.ihi.org/resources/Pages/Tools/TriggerToolforMeas...

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Note added at 1 hr (2022-10-13 17:35:31 GMT)
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6.2.5 Adverse drug event trigger tools
The trigger tool uses an efficient sampling technique to identify potential adverse events through an audit of medical records. Each tool includes a limited number of triggers that signal the most common types of adverse events or those that are most likely to cause serious harm. Triggers are included based on a literature review, expert opinion and testing for feasibility. When a trigger is found, the chart is reviewed to determine whether an adverse event has occurred. There are three types of triggers:
6. Identifying and reporting medication errors
36 Reporting and learning systems for medication errors: the role of pharmacovigilance centres
1. use of specific drug antidotes used to treat ADEs, for example, the use of vitamin K to treat over-anticoagulation with warfarin, or the prescription of flumazenil for over-sedation with benzodiazepines;
2. results from laboratory tests that may indicate an ADE; and
3. clinical events that may indicate an ADE.

Reporting and learning systems for medication errors: the role of pharmacovigilance centres

WHO Library Cataloguing-in-Publication Data
Reporting and learning systems for medication errors: the role of pharmacovigilance centres.
1.Medication Errors – prevention and control. 2.Pharmacovigilance.
3.Drug Monitoring. I.World Health Organization.

The reference above is a downloaded document published by the WHO.

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Note added at 2 hrs (2022-10-13 18:10:48 GMT)
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Detecting hypoglycaemia using electronic trigger drug alerts

The Pharmacy Medication Safety Team, working together with the EPMA team have designed a daily report to list details of ‘trigger’ drugs administered to inpatients at King’s College Hospital. The report is used to identify patients administered glucagon to aid identification of severe hypoglycaemic events. Electronic records of patients are retrospectively reviewed by pharmacists to ensure these events have been detected and acted on by non-specialist teams.

https://www.kingshealthpartners.org/assets/000/000/576/KHPJ4...

I would use '"trigger"' drugs'.

Helena Chavarria
Spain
Native speaker of: Native in EnglishEnglish
PRO pts in category: 381

Peer comments on this reference comment (and responses from the reference poster)
agree  Erzsébet Czopyk
3 hrs
  -> Thank you, Erzsébet :-)
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