Oder alternativ.
Doing business means making things happen.
Doing business means making a difference.
Doing business means getting your hands dirty.

Kommt halt alles auf den Kontext, die beabsichtigte Aussage, das Medium und den Stil des Textes an.

(Statt "doing business" könnte ich mir auch "entrepreneurship" vorstellen, falls sich das Ganze an (Jung-) Unternehmer wendet.

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Note added at 6 days (2015-07-02 08:56:52 GMT)
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I am running out of space here in the section below, so here's another comment.

I've long worked at a management consultancy, most of my clients are managers or entrepreneurs, and I've translated several books on management. One thing I know for sure is that none of my clients would like his or her business referred to as a synonym for "being busy". It's always about achieving something, getting things done, making a difference, having an impact. Of course, when businesses are "busy" it's never for nothing – but that phrase doesn't create the same feel as the German does.

We have this term "Macher" over here. That's not someone who is busy all the time - in fact, he or she might not even be busy fulltime. No: It's someone who gets things moving and ideally produces results.

That said, in this case there is a possibility that the author might be referring to hands-on involvement ("getting your hands dirty"). That is something I would definitely verify with him or her. My guess is, however, that this is about effectiveness - hence my first suggestion, which I feel also conveys a notion of getting active.