Glossary entry (derived from question below)
Sep 24, 2009 21:35
14 yrs ago
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German term
Mexico
Committed to Quality and Service
Native in: English (Variant: US) 
Works in: German to English
Nachkommen
German to English
Science
Medical: Pharmaceuticals
I'm translating a cooperation agreement for a clinical research study - mostly standard contract stuff. There are, however, a few sections that are beyond my expertise. I'm using 'derivatives' for Abkömmlinge, but I'm not sure whether the standard ‘descendants’ or ‘offspring’ would be appropriate for Nachkommen here.
Material im Sinne dieser Vereinbarung beinhaltet das ursprüngliche Material sowie von X GmbH überlassene Nachkommen. Nachkommen sind unmodifizierte Abkömmlinge des Materials, wie Zelle von Zelle, DNA von DNA und Plasmid von Plasmid.
Material beinhalten insbesondere die Nukleinsäuresequenzinformation der cDNA und die davon abgeleitete Aminosäuresequenz. Nachkommen sind beispielweise aus der Vervielfältigung stammende Plasmide, die die cDNA enthalten und Zellen, die solche Plasmide enthalten.
Material im Sinne dieser Vereinbarung beinhaltet das ursprüngliche Material sowie von X GmbH überlassene Nachkommen. Nachkommen sind unmodifizierte Abkömmlinge des Materials, wie Zelle von Zelle, DNA von DNA und Plasmid von Plasmid.
Material beinhalten insbesondere die Nukleinsäuresequenzinformation der cDNA und die davon abgeleitete Aminosäuresequenz. Nachkommen sind beispielweise aus der Vervielfältigung stammende Plasmide, die die cDNA enthalten und Zellen, die solche Plasmide enthalten.
Proposed translations
(English)
| 4 +4 | Descendants |
Blaess
|
References
| descendants |
Lirka
|
Change log
Sep 28, 2009 12:59: Kim Metzger Created KOG entry
Sep 30, 2009 14:37: Blaess changed "Edited KOG entry" from "<a href="/profile/9171">Kim Metzger's</a> old entry - "Nachkommen"" to ""descendants""
Proposed translations
+4
35 mins
Selected
Descendants
The following text deals with cells (stem cells) with the capacity of self-renewal - this means they are (more or less) genetically identical (thus, clones). This is the meaning of the context to - "Nachkommen" is defined as a derivative (of cell, DNA etc.) that is an unmodified "Abkömmling" (derivative [just perfect] (thus, a clone).
We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew.
Read more: http://www.faqs.org/patents/app/20080199849#ixzz0S42r0dLJ
6. A method according to claim 1, in which the progenitor cell line is established by exposing embryonic stem cells or their descendants to conditions which promote self-renewal of putative progenitor cells.
Read more: http://www.faqs.org/patents/app/20080199849#ixzz0S42OuJPZ
As an alternative you could use "clone" - but since the German text uses "Nachkommen" intentionally (not "Klone") the translation should keep the broader sense of meaning, too.
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Note added at 38 mins (2009-09-24 22:13:37 GMT)
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forgot the ref - sry:
http://www.faqs.org/patents/app/20080199849
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Note added at 41 mins (2009-09-24 22:17:00 GMT)
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More examples for descendants:
Upon expression of Cre protein, all cells and their descendants transcribe the lacZ gene, and therefore NC cell fate can be monitored directly with and without Foxd3 function.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=25...
We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew.
Read more: http://www.faqs.org/patents/app/20080199849#ixzz0S42r0dLJ
6. A method according to claim 1, in which the progenitor cell line is established by exposing embryonic stem cells or their descendants to conditions which promote self-renewal of putative progenitor cells.
Read more: http://www.faqs.org/patents/app/20080199849#ixzz0S42OuJPZ
As an alternative you could use "clone" - but since the German text uses "Nachkommen" intentionally (not "Klone") the translation should keep the broader sense of meaning, too.
--------------------------------------------------
Note added at 38 mins (2009-09-24 22:13:37 GMT)
--------------------------------------------------
forgot the ref - sry:
http://www.faqs.org/patents/app/20080199849
--------------------------------------------------
Note added at 41 mins (2009-09-24 22:17:00 GMT)
--------------------------------------------------
More examples for descendants:
Upon expression of Cre protein, all cells and their descendants transcribe the lacZ gene, and therefore NC cell fate can be monitored directly with and without Foxd3 function.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=25...
4 KudoZ points awarded for this answer.
Comment: "Thanks a lot, Blaess and lirka."
Reference comments
41 mins
Reference:
descendants
Found this reference where it's clear that it's the appropriate word. See page 21.
www.informatik.uni-rostock.de/.../genomics and proteomics I...
Genomes of eukaryotes
• majority of the DNA is in the nucleus, separated into
bundles (chromosomes)
– small amounts of DNA appear in organelles (mitochondria and
chloroplasts)
• within single chromosomes gene families are common
– some family members are paralogues(related)
• they have duplicated within the same genome
• often diverged to provide separate functions in descendants
(Nachkommen)
• e.g. human αand βglobin
– orthologuesgenes
• are homologues in different species
• often perform the same function
• e.g. human and horse myoglobin
– pseudogenes
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Note added at 44 mins (2009-09-24 22:20:20 GMT)
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in case the link does not open, google for bioinformatics, genomics and proteomics I
A pdf paper from Uni Rostock
www.informatik.uni-rostock.de/.../genomics and proteomics I...
Genomes of eukaryotes
• majority of the DNA is in the nucleus, separated into
bundles (chromosomes)
– small amounts of DNA appear in organelles (mitochondria and
chloroplasts)
• within single chromosomes gene families are common
– some family members are paralogues(related)
• they have duplicated within the same genome
• often diverged to provide separate functions in descendants
(Nachkommen)
• e.g. human αand βglobin
– orthologuesgenes
• are homologues in different species
• often perform the same function
• e.g. human and horse myoglobin
– pseudogenes
--------------------------------------------------
Note added at 44 mins (2009-09-24 22:20:20 GMT)
--------------------------------------------------
in case the link does not open, google for bioinformatics, genomics and proteomics I
A pdf paper from Uni Rostock
Peer comments on this reference comment:
| agree |
Blaess
: • often diverged to provide separate functions in descendants (Nachkommen) [links doesn´t work;( // thx - did so already - as the citation shows;)
2 mins
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please see my additional note re the link
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