--------------------------------------------------
Note added at 1 hr (2009-06-27 15:40:35 GMT)
--------------------------------------------------

Внешняя оболочка вириона состоит из структурных белков вируса **VP7 и VP4, определяющих выработку нейтрализующих антител** в организме хозяина, которые считаются важными для формирования защитного иммунитета.
www.who.int/immunization/Rotavirus_Rus.pdf

--------------------------------------------------
Note added at 1 hr (2009-06-27 15:44:35 GMT)
--------------------------------------------------

The core and inner capsid of the rotavirus particle are composed of structural proteins VP1 (125,000 Da), VP2 (94,000 Da), VP3 (88,000 Da), and VP6 (42,000 Da). The remaining **structural proteins VP4 (84,000 Da) and VP7 (34,000 Da), both of which ****induce antibodies**** with neutralizing activity**...
http://www.ncbi.nlm.nih.gov/pubmed/8381813?ordinalpos=10&ito...


--------------------------------------------------
Note added at 1 hr (2009-06-27 15:46:47 GMT)
--------------------------------------------------

Ротавирусы наиболее часто характеризуются по их **VP7 (G) и VP4(P)** протеинам. Это вирусные антигены, **на которые направлены нейтрализующие антитела**; они составляют основу классификации ротавирусов.
www.rotavirusvaccine.org/documents/Surv_protocol_Russian.pd...

--------------------------------------------------
Note added at 1 hr (2009-06-27 15:49:34 GMT)
--------------------------------------------------

Therefore, neutralizing antibody titers agains N-4 and S-4 reassortants can be used as a measure of the amounts of **neutralizing antibody directed against VP7 and VP4 protein**...
http://www.ncbi.nlm.nih.gov/pubmed/2166808?ordinalpos=12&ito...


--------------------------------------------------
Note added at 1 hr (2009-06-27 15:52:36 GMT)
--------------------------------------------------

**Both VP4 and VP7 can ****induce**** antibodies with neutralizing activity** in vitro (23, 26, 45), and antibodies to both of these proteins can passively protect experimental animals from rotavirus-induced diarrhea (41, 48).

http://jcm.asm.org/cgi/reprint/34/7/1694?view=long&pmid=8784...

--------------------------------------------------
Note added at 1 hr (2009-06-27 15:56:45 GMT)
--------------------------------------------------

****VP4 and VP7 independently **induce** neutralizing antibodies****. Antibodies to VP4 and VP7 can passively protect mice against rotavirus challenge (1, 5, 43,
44, 53).

http://jvi.asm.org/cgi/reprint/71/11/8707?view=long&pmid=934...

--------------------------------------------------
Note added at 1 hr (2009-06-27 15:59:20 GMT)
--------------------------------------------------

***VP4 and VP7 independently **elicit** antibodies capable of neutralizing rotavirus infectivity and inducing protective immunity**** (32).

http://jvi.asm.org/cgi/content/full/72/11/9233?view=long&pmi...

--------------------------------------------------
Note added at 1 hr (2009-06-27 16:03:42 GMT)
--------------------------------------------------

It was next determined whether protection in this model was dependent on the presence of homotypic **VP4 and VP7 proteins**, the outer capsid proteins of rotavirus responsible for ****stimulating**** neutralizing antibody.

http://jvi.asm.org/cgi/content/full/73/9/7565?view=long&pmid...