as opposed to "general knowledge"

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In addition, some educators, researchers, and reformers argue that teachers also need to develop strong “pedagogical content knowledge”—i.e., mastery of both subject-area knowledge and the most effective ways to teach students that specific subject. - http://edglossary.org/content-knowledge/

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You may demonstrate mastery of Subject Area Knowledge as follows:
For Bachelor's degree level subjects: Achievement of a passing score on the appropriate subject area examination* earned no more than ten (10) years prior to the date of application

For Master's degree level subjects: Completion of the required degree and content courses listed in State Board rule for the subject and achievement of a passing score on the appropriate Florida subject area examination* earned no more than ten (10) years prior to the date of application

For all subject areas:

http://www.fldoe.org/teaching/certification/general-cert-req...

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Highly reliable and valid; A recognized, accurate measure of college readiness and subject-area knowledge; - https://professionals.collegeboard.com/testing/sat-subject

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The subject area knowledge tested on the Chemistry 6–12 examination was identified and validated by committees of content specialists from within the state of Florida - http://www.fl.nesinc.com/pdfs/chemistry6-12_tig_3rd edition_... - page 5

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If you complete Step 1 and do not qualify for a Professional Certificate, you may receive an Official Statement of Status of Eligibility reflecting eligibility for a Temporary Certificate (Step 2), if you:

demonstrate mastery of subject area knowledge (see following page for options), or

http://yourcharlotteschools.net/pda/CertificationGeneral.htm