English to Russian Medical Medical (general) Cancer, Genetics

Дана схема с разными генами, мутации которых приводят к раку легкого, и соответствующими методами терапии. В одном блоке написано "no actionable alterations". Скриншот: https://i.imgur.com/L6l8y9P.png

Думаю о варианте "практически значимые", но не уверен, насколько это выражение подходит.

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The new buzzword in personalized cancer medicine is “actionable mutation”. This label is given to the genetic aberrations that are present in some patients’ tumors, and that are intended targets of new drugs.
https://bioethics.georgetown.edu/2015/09/acting-on-actionabl...

An actionable mutation is defined as a genetic aberration in the DNA (e.g., activating mutation) when detected in a patient’s tumor, and would be expected or predicted to affect a response to a targeted treatment available in basket or umbrella clinical trials, FDA-approved treatments, or be available for off-label treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140098/